Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation

evaluation of fat atrophy in patients with dermis fat graft of orbit by ct-scan

چکیده ندارد.

Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen

Peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator of adipocyte differentiation, has recently been connected with effector T cells, though its role is still not clear. Here, we investigated the roles of PPARγ in follicular helper T (TFH) cell responses regarding gender specificity. NP-OVA immunization in female but not male CD4-PPARγ(KO) mice induced higher proportions...

Regulation of T follicular helper cells by ICOS

T follicular helper (TFH) cells are gatekeepers of the humoral immune response. Without help from this CD4+ T cell subset, B cells cannot differentiate into high-affinity memory B cells and antibody-producing long-lived plasma cells which are the basis of protective immune responses. At the same time, dysregulated TFH cell responses are causative for many autoimmune disorders (reviewed in [1])....

Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells.

The durable alloantibody responses that develop in organ transplant patients indicate long-lived plasma cell output from T-dependent germinal centers (GCs), but which of the two pathways of CD4 T cell allorecognition is responsible for generating allospecific T follicular helper cells remains unclear. This was addressed by reconstituting T cell-deficient mice with monoclonal populations of TCR-...

Indirect-Pathway CD4 T Follicular Helper Are Mediated Exclusively by Germinal Center Alloantibody Responses